Early post-transplant donor-derived invariant natural killer T cell recovery predicts the occurrence of acute graft-versus-host disease and overall survival Running head: iNKT cells in human allogeneic HSCT
نویسندگان
چکیده
Marie-Thérèse Rubio, M.D, PhD , Lucia Moreira-Teixeira, PhD , Emmanuel Bachy, MD c,* , Marie Bouillié , Pierre Milpied, PhD., Tereza Coman, MD , Felipe Suarez, MD, PhD., Ambroise Marcais MD. , David Sibon MD, PhD , Agnès Buzyn, M.D, Ph.D., Sophie Caillat-Zucman, MD, Ph.D , Marina Cavazzana-Calvo, MD, Ph.D., Bruno Varet, MD., Michel Dy, PhD , Olivier Hermine, MD, Ph.D b,d,g,* and Maria Leite-de-Moraes, Ph.D..
منابع مشابه
Early posttransplantation donor-derived invariant natural killer T-cell recovery predicts the occurrence of acute graft-versus-host disease and overall survival.
Invariant natural killer T (iNKT) cells can experimentally dissociate GVL from graft-versus-host-disease (GVHD). Their role in human conventional allogeneic hematopoietic stem cell transplantation (HSCT) is unknown. Here, we analyzed the post-HSCT recovery of iNKT cells in 71 adult allografted patients. Results were compared with conventional T- and NK-cell recovery and correlated to the occurr...
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Background : Allogeneic hematopoietic stem cells transplantation (HSCT) is a valuable therapy for refractory acute leukemias, leukemias with a high risk for relapse, myelodysplastic syndromes, and chronic myeloid leukemia. HSCT outcome is dependent on several factors, including the stage of disease, degree of human leukocyte antigen (HLA) identity between donor and recipient, conditioning regim...
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Graft-versus-host disease (GVHD) is driven by extensive activation and proliferation of alloreactive donor T cells causing significant morbidity and mortality following allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are a potent immunoregulatory T-cell subset in both humans and mice. Here, we explored the role of adoptively transferred third-party C...
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Invariant natural killer T (iNKT) cells are powerful immunomodulatory cells that in mice regulate a variety of immune responses, including acute GVHD (aGVHD). However, their clinical relevance and in particular their role in clinical aGVHD are not known. We studied whether peripheral blood stem cell (PBSC) graft iNKT-cell dose affects on the occurrence of clinically significant grade II-IV aGVH...
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Dysregulated donor T cells lead to destruction of host tissues resulting in graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). We investigated the impact of highly purified (>95%) donor CD4(+) invariant natural killer T (iNKT) cells on GVHD in a murine model of allogeneic HCT. We found that low doses of adoptively transferred donor CD4(+) iNKT cells prot...
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